VEGFA and neoplasm: Pro-tumor vascular growth factors so far discovered include vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor (VEGFR), which stimulate tumor vascular endothelial cell growth and migration, increase tumor neovascularization permeability, and play an essential role in the angiogenesis process (Ferrara, 2004; Jiang and Liu, 2009; Claesson-Welsh and Welsh, 2013; Apte et al., 2019).