Mesenchymal cells and fibroblasts in tumor tissue secrete fibroblast growth factor (FGF), chemokine (C-X-C Motif) ligand 12 (CXCL12), and matrix metallopeptidase 2 (MMP2) to enhance tumor cell growth, invasion, and metastasis [(Hanahan and Coussens, 2012; Wang et al., 2017)]. This evidence concerns the gene CXCL12 and neoplasm.