Thirdly, mutations and deletions of p53, SMAD4, and deleted in colon cancer (DCC) occur early in CAC, whereas the loss of APC and KRAS mutations occur late in CAC, exactly the opposite of the period in which sporadic CRC molecular mutations occur (Nagao-Kitamoto et al., 2022). The gene discussed is TP53; the disease is colorectal carcinoma.