For example, inhibition of Notch1 in glioblastoma cell lines induced the oncogenic function of autophagy; however, in combination with γ-secretase inhibitor RO4929097 (GSI) and a natural compound, Resveratrol, resulted in the accumulation of autophagosomes and subsequent growth inhibition by inducing apoptosis (Giordano et al., 2021). The gene discussed is NOTCH1; the disease is glioblastoma.