NOTCH1 and breast cancer: These results along with the well-established oncogenic role of Notch1 in BC (Reedijk et al., 2005; Hu et al., 2006; Mohammadi-Yeganeh et al., 2015), where its increased expression has been shown to enhance metastatic phenotype (Zang et al., 2010; Li et al., 2015), suggests that inhibition of Notch1 could eliminate BCSCs and increase drug sensitivity.