To investigate the anti-obesity mechanism of PD, we examined the expression of thermogenic proteins PRDM16 and UCP1, mitochondrial biosynthesis-related protein PGC-1α, TFAM and cAMP pathway related protein P-CREB in adipose tissue after (20R)-panaxadiol administration. Here, CREB1 is linked to obesity due to melanocortin 4 receptor deficiency.