NFKB1 and metabolic dysfunction-associated steatotic liver disease: Inflammation and fibrosis are major hallmarks of NAFLD-associated chronic conditions like HCC, where NF-κB acts as the master regulator of inflammation and inflammatory cytokine production (Elsharkawy and Mann, 2007; Santhekadur et al., 2012; Santhekadur et al., 2014).