In our recent study, we showed that withaferin A, which is a multifaceted drug from the ashwagandha plant, has an inhibitory effect on hepatocellular carcinoma via LXR-α activation and inhibits the NF-κB transcription factor (Santhekadur, 2017; Shiragannavar et al., 2021; Shiragannavar et al., 2022). This evidence concerns the gene NR1H3 and hepatocellular carcinoma.