Analyzing individual targets identified ADRB1 (Beta: 0.192; 95% CI: 0.070, 0.314; adjusted p = 3.19E-02; per 10-mmHg lower) by ‘encoding region-based method’ and KCNH2 (Beta: −0.650; 95% CI: −0.983, −0.318; adjusted p = 3.64E-03; per 10-mmHg lower) by “eQTL-based method” as significant targets that may drive the causal effect of BB on PD AAO (Supplementary Table S15). Here, ADRB1 is linked to Parkinson disease.