Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor found activated due to different genetic alterations (chromosomal translocations, substitution mutations and gene amplification) in many cancers including anaplastic large-cell lymphomas (ALCL) and diffuse large B-cell lymphomas (Webb et al., 2009). The gene discussed is NTRK1; the disease is anaplastic large cell lymphoma.