The demonstration of the effectiveness of the monocyclic Isoxazoles in inhibiting FXa has even encouraged researchers to develop isoxazole FXa inhibitors, as Isoxazoles play important roles in cardiovascular disease, calcium regulation (Wittenberger, 1995; Johansen et al., 1998), and Alzheimer’s disease (Regine Riess et al., 1997). This evidence concerns the gene F10 and early-onset autosomal dominant Alzheimer disease.