Dimensions of the aortic root (2.71 cm), left atrium (3.27 cm), and left ventricular mass index (79.95) were relatively higher in HIV-positive subjects on HAART (p < 0.05). LVEF and wall thickness are higher in the HIV-positive, HAART-naive group. However, clinical features of HIV infection, such as immunosuppression and a reduced CD4 cell count, were more prevalent in HIV-positive patients who were HAART-naive than in HIV-positive patients on HAART. This evidence concerns the gene CD4 and HIV infectious disease.