AFP: alpha-fetoprotein; BCLC: Barcelona Clinic Liver Cancer; BSC: best supportive care; ECOG-PS: Eastern Cooperative Oncology Group performance status; HBV: hepatitis B virus; HCV: hepatitis C virus; HCC: hepatocellular carcinoma; HER2: human epidermal growth factor receptor 2; IQR: interquartile range; NASH: non-alcoholic steatohepatitis; RAF: radiofrequency ablation; TACE: transarterial chemoembolization. This evidence concerns the gene AFP and metabolic dysfunction-associated steatohepatitis.