TERT and neoplasm: The genetic analysis allowed the identification of the main drivers responsible for tumor initiation and progression, such as telomere reverse transcriptase (TERT) and fibroblast growth factor 19 (FGF19) mutations, inactivation of tumor antigen p53 (TP53), and activation of Wnt, mammalian target of rapamycin (mTOR), and RAS signaling pathways [33].