Histologically, PMBCL overlaps with nsHL in that PMBCL expresses B-cell markers (such as CD19, CD20, CD22, and CD79a) but lacks expression of surface or even cytoplasmic immunoglobulin (Ig), despite expression of the Ig co-receptors/antigens (such as CD79a), unlike other B-cell lymphomas [24]. The gene discussed is CD79A; the disease is nodular sclerosis classical Hodgkin lymphoma.