Both opioids and steroids suppress the hypothalamic-pituitary axis causing decreased ACTH levels and cortisol; however, the treatment for Cushing's syndrome is a withdrawal of the offending agent, whereas the treatment of opioid-induced adrenal insufficiency is glucocorticoid replacement [8]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.