Figure 2 shows both autosomal dominant and recessive genes involved in the etiopathogenesis of PD where organelles such as vesicles, mitochondrion, proteasome, and lysosomes with the genes GAL, SNCA, DJ1, PARKIN, GBA, HRTA 2, and FBXO7 on mutation form accumulations of misfolded proteins. The gene discussed is SNCA; the disease is Parkinson disease.