SLC5A2 and orthostatic hypotension: A combination of SGLT2 inhibitors with a loop diuretic may result in reducing the interstitial volume compared with intravascular volume, thus resulting in less compensatory activation of RAAS [11]. It is suggested that the physicians monitor the volume status of the patients after initiation of SGLT2 inhibitors and decrease the dosing of loop diuretics in case dizziness or orthostatic hypotension is encountered [12].