The multinomial regression analysis exploring the distribution of age, sex, education and the APOE ε4 status among the AT(N) groups, using the clinical variables (hypertension, diabetes mellitus, dyslipidemia, heart disease, COPD, smoking habit) as adjusting factors, showed that age and the APOE ε4 status had a significant effect, so both were included as adjusting factors in the final analysis (Supplementary Table 2). Here, APOE is linked to chronic obstructive pulmonary disease.