None of the three CSF biomarkers showed a significant correlation with any macular VD measurements, adjusted by age, APOE ε4 status, hypertension, diabetes mellitus, dyslipidemia, heart disease, COPD, smoking habit and CSF technique (all r < 0.13; p ≥ 0.133) (see Table 3). This evidence concerns the gene APOE and chronic obstructive pulmonary disease.