The results suggested that NOS (OR = 3.44, 95% CI: 1.41 – 8.36, P = 0.007), HCY (OR = 1.29, 95% CI: 1.16 – 1.45, P < 0.001), CRP (OR = 1.15, 95% CI: 1.07 – 1.23, P < 0.001), and SS (OR = 3.12, 95% CI: 1.03 – 9.83, P = 0.046) were independent predictors of death within 1 year in AIS patients. The gene discussed is CRP; the disease is androgen insensitivity syndrome.