fused IFNγ to the N‐terminal region of SipB by overexpressing IFNγ in attenuated S. typhimurium (S. typhimurium (IFN‐γ)), which effectively suppressing B16F10 melanoma tumor growth and prolonging the mice survival.[202] Besides, FlaB,[115] CCL21,[111c] IL‐2,[203] IL‐18,[196] etc. have also been used as immunomodulators delivered by bacteria for cancer therapy. This evidence concerns the gene IFNG and melanoma.