The protein-protein interaction (PPI) network was illustrated based on the QTHX targets on NASH with the STRING database (Figure 1(B)) and the PPI core network (Figure 2(A)), was settled at 10 hub nodes, and 35 edges, which includes MAPK14, AKT1, FOX, HIF1A, RELA, JUN, TP53, MAPK3, CDKN1A, MAPK1. This evidence concerns the gene CDKN1A and metabolic dysfunction-associated steatohepatitis.