Clinically, systemic inflammation in COPD is often identified by the increase of several biomarkers in the circulation, such as C‐reactive protein (CRP), IL‐6, IL‐8 (CXCL8), TNF‐α, fibrinogen and leukocyte (Cardoso et al., 2021). Here, CXCL8 is linked to chronic obstructive pulmonary disease.