CALR, also known as ER resident protein 60, is a protein that binds to calcium ions; CALR acts as a molecular chaperone and involves in protein quality control and calcium ion homeostasis.23 Previous study reported that cancer cells undergoing RT were able to translocate intracellular CALR to their plasma membrane surface, served as an “eat me” signal, and resulted in ICD.24 However, such radiation-triggered CALR exposure on tumor cell surface was unsatisfied. Here, CALR is linked to cancer.