P2RX7 and impulse control disorder: ATP release into extracellular space is one of the hallmarks of ICD.14 Extracellular ATP could mediate DC maturation through the binding of P2X7 receptors, upregulating inflammasomes, and promoting inflammatory cytokines secretion.22 To determine the secretion of ATP among dying tumor cells in response to ERAD inhibitors, luminescent assays were conducted.