In addition to the ER, a considerable amount of CALR was found on the surface of malignant tumor cells.45 Although CALR overexpression was associated with a higher density of immune cell infiltration and favorable survival in malignant cancer, whether these CALRs were expressed on cell surface or mainly from intracellular space remained unclear.42 Therefore, further investigation is needed to clarify the effect of intracellular CALR on cancer patient prognosis. The gene discussed is CALR; the disease is cancer.