Cysteine β-synthase (CBS) and cysteine γ-lyase (CSE) catalyze Hcy catabolism through the transsulfuration pathway, and inadequate systhesis of these two enzymes is often present in renal diseases.40 We observed that 2K1C induced downregulation of CBS but not CSE expression (Supplementary Fig. 1h, i). This evidence concerns the gene CBS and kidney disorder.