Our concentrative and systematic study of BRIP1 in pan-cancer suggested that there are significant associations between BRIP1 expression, genetic alterations, DNA methylation, activation or inhabitation of cancer-related pathways, immune cell infiltration, MSI/TMB/neoantigen, immune pathways, and immune checkpoints across multiple human cancers, which would provide a novel insight in understanding the genetic landscape and biologic function of BRIP1 in cancers. The gene discussed is BRIP1; the disease is cancer.