We then performed a Cox regression analysis to explore the role of BRIP1 expression and several clinical characteristics in the survival of different cancers, and the results verified that BRIP1 acted as a risk factor in KIRP, ACC, LGG, MESO, and PAAD patients, and played a protective role in COAD, READ, STAD, and THYM patients. Here, BRIP1 is linked to cancer.