When adjusted for age, BMI, hypertension, heart rate, BNP, and serum creatinine in model II, the TyG index as a continuous variable was an independent risk factor for a mid/high SYNTAX score in individuals with normoglycemia (OR, 2.902; 95% CI 1.453–5.797; P = 0.003), prediabetes mellitus (OR, 2.321; 95% CI 1.213–4.441; P = 0.011), and diabetes mellitus (OR, 2.666; 95% CI 1.585–4.486; P < 0.001). This evidence concerns the gene NPPB and diabetes mellitus.