Patients with a SYNTAX score > 22 were older and had higher prevalence rates of hypertension, diabetes mellitus, AMI, MVD, left main lesion, calcified lesions, thrombosis, long lesion, and chronic total occlusion, increased levels of HR, cTnT, BNP, Scr, FBG, TG, and the TyG index, and a larger number and length of stents. This evidence concerns the gene NPPB and Hypertension.