GLP-1 receptor agonists have been shown to reduce sodium reabsorption and promote diuresis through actions in the renal proximal tubule.5,6 GLP-1 receptors are expressed in the choroid plexus, the predominant CSF-secreting structure in the brain.7,8 Our preliminary data have shown that GLP-1 receptor agonism reduces CSF secretion and intracranial pressure (ICP) in an in vivo rodent model with elevated ICP.7 The reduction in ICP was of a greater magnitude to that observed with the commonly used drugs in idiopathic intracranial hypertension (IIH).9 Here, GLP1R is linked to pseudotumor cerebri.