Our findings of lower ITGAL mRNA expression in cases with lymphovascular invasion (p = 0.0427) and extrathyroidal extension (p = 0.0111) and high mRNA expression in cases with lymphocytic infiltrate (p = 0.0244), reinforce a tumor suppressive role for LFA-1 in thyroid tumorigenesis. The gene discussed is ITGAL; the disease is thyroiditis.