In addition, endometrial cancer mouse models with conditional inactivation of phosphatase and tensin homolog (Pten) and the AT-rich interaction domain 1 A (Arid1a) genes, demonstrate aberrant TGFβ signaling, further supporting that inactivation of the TGFβ pathway contributes to the metastatic potential of endometrial tumors. The gene discussed is ARID1A; the disease is endometrium neoplasm.