ACVR1C and tumor of uterus: We profiled the data from uterine tumors deposited to the cBioPortal of Cancer Genomics for mutations of the TGFβ signaling pathway20,21 and identified several mutations in TGFβ-related receptors (TGFBR1, TGFBR2, ACVR1B, ACVR1C, ACVR2A, ACVR2B) and transcription factors (SMAD2, SMAD3, SMAD4) (Supplementary Fig. 1a).