In 2022, the FDA approved PluvictoTM (177Lu-PSMA-617 or lutetium Lu 177 vipivotide tetraxetan) for the treatment of adult patients with PSMA-positive mCRPC who have been treated with androgen receptor pathway inhibition and taxane-based chemotherapy [13]. Despite these exciting development of PSMA targeted radio-ligand therapies, there are several limitations: (1) Radio-labeled PSMA-617 causes persistent xerostomia in patients, impairing quality of life [14]; (2) PSMA is heterogeneously expressed, especially in treatment emergent small cell neuroendocrine prostate cancer [15]. The gene discussed is FOLH1; the disease is xerostomia.