Eleven pathways were associated with schizophrenia, including extracellular matrix (ECM) receptor interaction, sphingolipid signaling, PI3K-Akt signaling, cholinergic synapse, phosphatidylinositol signaling system, estrogen signaling pathway, ErbB signaling pathway, mTOR signaling pathway, dopaminergic synapse, ras signaling pathway, and TGF-beta signaling pathway44–54, whereas seven pathways were associated with MDD (Table S2). Here, AKT1 is linked to major depressive disorder.