EZH2 and melanoma: In melanoma, EZH2 represses genes associated with tumor suppression, cell differentiation, cell cycle inhibition, metastasis, and antigen processing and presentation [7, 16, 17], and is upregulated transcriptionally by E2F and c-myc and suppressed by differentiation-promoting factors such as pRb and p16INK4b [18, 19].