To identify EZH2-bound E3 ligases in melanoma, EZH2-co-immunoprecipitated lysates obtained from a variety of melanoma cell lines (A375, 28:B4:F3, B16-F10, LM-MEL45 and IGR37) were subjected to Liquid Chromatography-Mass Spectrometry (LC-MS). Here, EZH2 is linked to melanoma.