Rather, we found that melanoma cells with high EZH2 expression generally formed partially pigmented tumors following subcutaneous implantation, with non-pigmented metastatic foci in the liver, and that UBE2L6 over-expressing melanoma cells with low EZH2 formed highly pigmented tumors with either no or only small and pigmented metastatic foci. This evidence concerns the gene EZH2 and melanoma.