EZH2 and neoplasm: EZH2 suppresses gene transcription by catalyzing trimethylation of histone H3 at lysine 27 (H3K27me3), plays an important role in maintaining cells in a progenitor-like state through silencing genes associated with differentiation [5, 6], is aberrantly overexpressed in multiple cancers [5–12] and functions to promote tumor growth and metastasis in models of malignant disease [13].