In melanoma, switching between invasive and proliferative states was shown to be regulated by enhancer of zeste homolog 2 (EZH2) [3, 4], with the proliferative state characterized by high expression of the melanocyte transcription factor MITF and low expression of BRN2 and AXL, and opposite expression patterns found in the invasive state. The gene discussed is MITF; the disease is melanoma.