The same trend for increased insoluble protein ratios was also observed for insoluble total tau but did not reach statistical significance for the effect of disease (P = 0.067). However, the ratios of insoluble tau isoform 0N3R (PD vs. Control 3.9 ± 0.4 vs. 2.2 ± 0.5, F (1.22) = 6.58, P = 0.018) was significantly higher in PD, independent of the MAPT haplotype. The gene discussed is MAPT; the disease is Parkinson disease.