Furthermore, changes in locomotor activity, anxiety-like behavior, altered stress response, and social interaction occur in animal models with disrupted FGF ligands or FGF receptor 1 (FGFR1) dependent signaling in the forebrain [3, 10, 12–16], implicating FGF signaling in basic brain development and functioning relevant to psychiatric illness. Here, FGFR1 is linked to Anxiety.