CCL2 and Cognitive impairment: Similar to PDGBA_WT, Cox-regression analyses in PDGBA patients revealed an impact of age and/or disease duration as confounding interaction with the respective inflammatory marker on the duration until the development of cognitive impairment (ICAM-1: age p = 0.035, dd p = 0.053; interleukin-8: dd p = 0.076; MCP-1: dd p = 0.048, MIP-1 beta: dd p = 0.062; SCF: dd p = 0.094; VEGF: age p = 0.074, dd p = 0.040).