(II)Higher CSF levels of ICAM-1, interleukin-8, MMP3, MIP-1 beta, SCF and VEGF were associated with higher CSF levels of neurodegenerative/PD-specific biomarkers, namely Aβ1-42, t-Tau, p181-Tau, NFL and α-synuclein in the total PD cohort and also after stratification by sex. This evidence concerns the gene CCL4L2 and Parkinson disease.