Cox-regression analyses revealed a relevant impact of age and/or disease duration as confounding interaction with the respective inflammatory marker on the duration until the development of cognitive impairment (ICAM-1: age p = 0.024, dd p = 0.010; interleukin-8: age p = 0.024, dd p < 0.001; MCP-1: dd p < 0.001; MIP-1 beta: dd p < 0.001; SCF: dd p < 0.001; VEGF: dd p < 0.001). Here, CXCL8 is linked to Cognitive impairment.