In NONO-TFE3 translocation renal cell carcinoma (tRCC), the NONO-TFE3 fusion protein can directly inhibit tumor necrosis factor receptor-associated factor 3-interacting protein 2-antisense 1 (TRAF3IP2-AS1) expression. Here, TFE3 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.