NOTCH1 and breast carcinoma: Moreover, another important protein, TGF-β, guides Notch1 to drive EMT.160 A study by Zeng et al. showed that inhibition of Notch1 reverses the EMT process and overcomes cisplatin resistance in breast cancer cells.161 The data also suggested that high expression of Notch1 predicts a poor prognosis in TNBC patients.