Interestingly, EZH2 was recently found to support TCP through MET facilitation and tumor colonization.275 Overexpression of EZH2 was associated with the conversion of prostate adenocarcinoma to neuroendocrine prostate cancer (NEPC), which is a more aggressive variant.61,276 Inhibition of EZH2 can reverse the cell lineage switch, leading to a decrease in neuroendocrine related key factors and restoring the sensitivity of NEPC cells to enzalutamide. Here, EZH2 is linked to prostate adenocarcinoma.