ID3 acted as a transcriptional repressor of sex-determining region Y-box 10 (SOX10) and MITF, thereby promoting tumor cell transformation to a drug-resistant phenotype.122 Moreover, Sun et al.123 also observed an increase in the percentage of SOX10low EGFRhigh melanoma cells after BRAFi and MEKi treatment. Here, MITF is linked to neoplasm.