The impact of other EMT-TFs on metastasis was then extensively investigated in different types of cancers.33 For example, depletion of Zeb1 was found to markedly inhibit pancreatic ductal adenocarcinoma progression towards metastatic type.34 Zeb1 was also found to function as a key master regulator of multiple EMT-TFs and metastasis in breast cancer.33 The MET program, in contrast, presumably functions during metastasis when the migratory CSCs settle down and adapt to a new microenvironment. This evidence concerns the gene ZEB1 and pancreatic ductal adenocarcinoma.