HIF1A and cancer: For example, by blocking the nuclear translocation of HIF-1α, 6-gingerol successfully inhibits the EMT pathway and suppresses proliferation and metastasis of lung cancer.369 Salidroside enhances antitumor efficacy of platinum drugs in HCC by promoting the degradation of HIF-1α, thereby inhibiting the EMT of HCC cells.371 Similarly in lung cancer, by inhibiting hypoxia-activated NF-κB signaling pathway and EMT, a ginseng-extracted 20(R)-Ginsenoside (Rg3) increases the susceptibility of cancer cells to cisplatin treatment.345