AR and pachyonychia congenita: AR is known as a ligand-activated transcription factor which regulates gene expression in the prostate epithelium.113 AR-targeted inhibitors, including bicalutamide and enzalutamide, have been developed for PC treatment.114,115 However, upon castration therapy, evading mechanisms are launched by AR amplification, point mutation, splicing variants, as well as substitution of AR functions by glucocorticoid receptors.116