Among the gene sets we identified to be positively or negatively enriched in therapy-resistant glioblastoma cell lines (Fig. 5a, b), we decided to concentrate on REACTIVE_OXYGEN_SPECIES_PATHWAY, MTORC1_SIGNALING and TNFA_SIGNALING_VIA_NFKB [10, 11, 77]. This evidence concerns the gene NFKB1 and glioblastoma.