The interaction between Siglec-10 on host APCs and CD24 on donor T cells inhibits the expansion and function of T cells, Reducing graft-versus-host disease (GVHD) in Allogeneic Hematopoietic cell transplantation.219 In addition to affecting T cell function, Siglecs can also induce tolerance of B cells. The gene discussed is CD24; the disease is graft versus host disease.