However, NETs are considered to be deleterious in a variety of sterile inflammation, including atherosclerosis, vasculitis, thrombosis, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), lung injury, and tumor metastasis.106,107 In conclusion, HMGB1 is secreted extracellular as DAMPs or a cytokine of immune cells, mediates the recruitment and infiltration of immune cells via binding to receptors, stimulates and amplifies inflammatory signals, and indirectly stimulates the activation of innate cells. This evidence concerns the gene HMGB1 and neoplasm.