CDX2 and teratocarcinoma: Subcutaneous injection of the genetically engineered D22 TPCs generated avatars that recapitulate the recognizable phenotypic and morphological features of follicular cell-derived TC histotypes, whereas D6 cells-derived xenograft masses resembled a teratocarcinoma phenotype expressing S-100, CDX2, Oct3/4 and p40 (Fig. 1G and Supplementary Fig. 2d).