The expression of membrane-anchored protein a disintegrin and metalloproteinase domain 8 (ADAM8) in glioblastoma cells and macrophages mediates OPN secretion and suppresses angiogenesis via JAK/STAT3 pathway, may also contributes to the formation of the specific isoform of OPN in ECM [531]. This evidence concerns the gene SPP1 and glioblastoma.