In pancreatic cancer, TAM-derived C-X-C motif chemokine ligand 3 (CXCL3) targets CAFs’ C-X-C motif chemokine receptor 2 (CCR2) to mediate CAF-myofibroblasts (myCAF) transition, subsequent type III collagen generation and tumor metastasis [75]. Here, CXCL3 is linked to familial pancreatic carcinoma.