The breakthrough of stromal cells role in pancreatic cancer immunosuppression is the identification of different subtypes of CAFs, which preliminarily classified into αSMA-expressing myCAFs, associated with desmoplastic stroma generation, and IL-6/leukemia inhibitory factor (LIF)-expressing inflammatory fibroblasts (iCAFs), associated with inflammation [337]. This evidence concerns the gene LIF and familial pancreatic carcinoma.