Chitinase-3-like protein 1 (CHI3L1/YKL-40), a glycoprotein secreted by various cancer cells and stromal cells, enhances the synergic effect of syndecan-1 and β3 integrin and activation of FAK/ERK pathway in ECs to promote angiogenesis in breast and colon cancer [414, 415]. Here, CHI3L1 is linked to cancer.