Intriguingly, a specific clone of CAFs associated with ECM (eCAFs) is identified in pancreatic cancer [339] and gastric cancer [340], and recently identified Endo180 and paired related homeobox 1 (Prrx1) may be significant genes associated with the function and plasticity of eCAFs [341, 342]. Here, PRRX1 is linked to familial pancreatic carcinoma.