PTK2 and neoplasm: Mechanically, losing β3 integrin in mural cells triggers phosphorylate FAK/HGFR/p65 and upregulation of CXCL1, C–C motif chemokine ligand 2 (CCL2) and TIMP-1, while CCL2 stimulates tumor progression via MAP/ERK kinase 1 (MEK1)-ERK1/2-ROCK2 pathway [421].