A significant observation demonstrates that losing of hyaluronan and proteoglycan link protein 1 (HAPLN1), a hyaluronic and proteoglycan link protein, in skin could trigger collagen alignment in melanoma, which hampers CD8 T cell migration whereas enhances infiltration of myeloid-derived suppressor cells (MDSCs) and Treg in melanoma [476]. This evidence concerns the gene HAPLN1 and melanoma.