Multivariate regression analysis showed that ANKRD22 (HR: 1.22, 95% CI 0.96–1.55; P = 0.098), ARNTL2 (HR: 1.71, 95% CI 1.19–2.46; P = 0.003), DSG3 (HR: 1.15, 95% CI 1.01–1.31; P = 0.029), KRT7 (HR: 1.19, 95% CI 0.97–1.46; P = 0.0093), PRSS3 (HR: 1.23, 95% CI 1.04–1.44; P = 0.013) were prognostic factors in pancreatic cancer patients. The gene discussed is PRSS3; the disease is familial pancreatic carcinoma.