The gating strategies for monocytes in peripheral blood was shown in Fig. 2A. The percentages of intermediate monocytes (CD14 +  + CD16 + monocytes) and nonclassical monocytes (CD14 + CD16 +  + monocytes) were higher in UC patients with symptoms of anxiety/depression [17.29(10.00,21.40) vs. 8.73(6.26,11.50), P = 0.0004; 7.46 ± 0.76 vs. 4.18 ± 0.45, P = 0.0010] (Fig. 2B). The gene discussed is CD14; the disease is depressive symptom measurement.