RB1CC1 and Hepatic steatosis: Although these findings on lipophagy in cultured cells are interesting, mice with genetic deletion of autophagy-related genes [ie, Atg5, Atg7, or Fip200 (alias Rb1cc1)] do not develop hepatic steatosis in response to physiologic starvation or partial hepatectomy or high-fat diet feeding.53, 54, 55, 56 Decreased steatosis in autophagy-deficient livers occurs partially due to the accumulation of nuclear receptor co-repressor 1, which inhibits liver X receptor α–mediated de novo lipogenesis and LD biogenesis.54