Furthermore, our previous comparative microcalorimetric studies on human CaM (hCaM) and CaM from the malaria parasite Plasmodium falciparum (pfCaM, a potential antimalarial target (56, 57), sharing a 89% identity with hCaM) revealed that even minor variations of the CaM sequence can result in notable differences in its interaction with melittin: while the interaction of melittin with both CaMs could be characterized by positive binding enthalpies, ΔH values obtained for pfCaM were somewhat smaller than values for hCaM. This evidence concerns the gene CD44 and malaria.