Univariate Cox regression analysis found that T3 & T4 stage, N1 stage, N2 stage, M1 stage, III & IV pathological stage, lymphatic invasion, tumor complete response after primary therapy, age > 65 years old, BMI ≥ 25 kg/m2, R1 & R2 residual tumor, carcinoembryonic antigen (CEA) > 5 ng/mL, and KCNK9 expression level was associated with colon cancer patients’ OS (Table 2). This evidence concerns the gene CEACAM5 and neoplasm.