Furthermore, lncRNA OIP5-AS1/miR-448/TLR3/NF-κB, lncRNA BZRAP1-AS1/miR-1286/COL5A2 and LncRNA XIST/miR-126-3p/NF-κB have been found to strengthen proliferation and restrict apoptosis of RA-FLS [49,54,58]. Here, TLR3 is linked to rheumatoid arthritis.