After biological validation in 20 RA patients and 20 healthy controls, seven lncRNAs (C5orf17, LINC01189, LINC01006, MAPKAPK5-AS1, DSCR9, MIR22HG and ENST00000619282) were validated as the most significantly differentially expressed lncRNAs, which were correlated with clinical indicators and self-cognitive ability of patients [90]. The gene discussed is MAPKAPK5; the disease is rheumatoid arthritis.