The work of Andueza et al. [6] confirmed that NOX5 activity contributes to the proliferation of the cell line as well as the increased production of collagen type I, pointing to a possible implication of the oxidase in the initiation and progression of liver fibrosis, in line with the role previously reported played by NOX1,NOX2, and NOX4 [70]. The gene discussed is NOX5; the disease is Hepatic fibrosis.