In some of those new roles, as in the field of metabolic diseases, liver fibrosis, pulmonary hypertension, neurodegenerative disorders, or neuroinflammation, the precise effect of the activity of NOX5 has to be better characterized, since it is not still clear whether its activity is being part of the damage, or an attempt of the body to activate compensatory mechanisms to solve an insult [6, 38, 39, 87, 100]. This evidence concerns the gene NOX5 and metabolic disease.