NOX5 and melanoma: Elevated NOX5 levels have been also reported in various types of tumors and cancer cell lines (lymphoma, Barrett’s esophageal adenocarcinoma, gastric, melanoma, colon, breast, and prostate), where an increase in ROS levels correlates with increased cell proliferation, DNA damaged, angiogenesis, and reduced apoptosis [7, 9, 33, 37, 69, 93].