TEPOC exhibited an AUC of 0.858 (95% CI 0.790–0.926) to detect early-stage ovarian cancer, being not significantly different from that of CA125 [0.749 (95% CI 0.660–0.839); P = 0.06; Fig. 4C; Table S3). The gene discussed is MUC16; the disease is ovarian carcinoma.