Recent studies also revealed that fusions between IDR-rich NUP98 and TFs or epigenetic modifiers (such as driver genes in pediatric leukemias—homeobox protein Hox-A9 and lysine-specific demethylase 5A), induced aberrant transcriptional activity by phase separation, leading to cancer (Ahn et al., 2021; Chandra et al., 2022; Terlecki-Zaniewicz et al., 2021). Here, KDM5A is linked to cancer.