GPR176 and neoplasm: GPR15 modified regulatory T‐cell‐guided antitumor immunity, promoted intestinal tumorigenesis, and regulated the tumor microenvironment.[18] Moreover, CCK2R, known for its transporting role in cholecystokinin, regulated progastrin‐dependent tumor development in CRC.[19] We previously determined the role of GPR56 in promoting cell proliferation in CRC via the PI3K/AKT signaling pathway.[20] To further our understanding of GPCRs in CRC, we used bulk screening and identified an orphan GPCR, GPR176, which was overexpressed and highly correlated with poor prognosis in CRC.