In both Gpr176−CKO mice model and the subcutaneous tumor model, loss of GPR176 significantly diminished BNIP3L phosphorylation, while a slight alteration in PINK1 phosphorylation level was observed, suggesting that GPR176 mainly modulated BNIP3L phosphorylation both in vitro and in vivo (Figure 5G). The gene discussed is GPR176; the disease is neoplasm.