GPR15 modified regulatory T‐cell‐guided antitumor immunity, promoted intestinal tumorigenesis, and regulated the tumor microenvironment.[18] Moreover, CCK2R, known for its transporting role in cholecystokinin, regulated progastrin‐dependent tumor development in CRC.[19] We previously determined the role of GPR56 in promoting cell proliferation in CRC via the PI3K/AKT signaling pathway.[20] To further our understanding of GPCRs in CRC, we used bulk screening and identified an orphan GPCR, GPR176, which was overexpressed and highly correlated with poor prognosis in CRC. Here, GPR15 is linked to colorectal carcinoma.