Four groups of mice were injected with differentially pretreated CRC cells: GPR176 vector control (Vec), GPR176 overexpression (GPR176), GPR176‐OE combined with GNAS overexpression (GPR176+GNAS), and GPR176 overexpression combined with GNAS knockdown (GPR176+shGNAS). This evidence concerns the gene GNAS and colorectal carcinoma.