GPR176 and colorectal carcinoma: CREB, as the main substrate of PKA, stimulates the transcription of certain genes, which further participate in mitophagy.[24] Additionally, the MAPK/ERK pathway maintains proper mitochondrial functions.[25] Although our results showed that CREB, but not Raf, was regulated by GPR176‐mediated cAMP/PKA, but further validation confirmed that CREB might not be involved in GPR176‐mediated mitophagy, suggesting that PKA‐phosphorylated CREB was not the primary factor for impaired mitophagy in CRC.