GPR176 and colorectal carcinoma: Canonically, second messenger cAMP, produced following GPCR activation, plays a fundamental role in cellular metabolism as an allosteric activator of PKA.[12] The cAMP/PKA pathway modulates mitophagy via the phosphorylation of PKA substrates.[13] As a member of GPCRs family, GPR176 is a cell surface receptor involved in responses to hormones, growth factors, and neurotransmitters.[14] GPR176 has agonist‐independent constitutive activity, which allows it to reduce the synthesis of cAMP without ligand involvement.[15] Until now, the role of GPR176 in CRC has not been reported.