We examined 11 target cytokines (IL‐1b, TNF‐a, CRP, secreted protein acidic rich in cysteine [SPARC], fibroblast growth factor 21 [FGF21], IL‐6, IL‐8, IL‐10, IL‐13, IL‐15, and IL‐18) known to be altered in the presence of obesity and/or T2D, and to be regulated by acute and/or chronic exercise (Garneau & Aguer, 2019). This evidence concerns the gene FGF21 and obesity due to melanocortin 4 receptor deficiency.