Although no effect of time or type of exercise was detected for SPARC, there was a significant interaction between the presence of T2D in the participants and the plasma SPARC levels as a function of training modality (p = 0.0124), as well as between T2D, the training modalities and the effect of time (p = 0.0415) (Figure 2a). The gene discussed is SPARC; the disease is type 2 diabetes mellitus.