Functions of GLP‐1 and GLP‐1RAs in the liver as well as in adipose tissues have provided plausible explanations for their effectiveness in treating T2D subjects with severe insulin resistance as well as their profound effect on lipid homeostasis (Hein et al., 2013; Jin & Weng, 2016; Taher et al., 2014). This evidence concerns the gene GCG and Insulin resistance.